Genomic Analysis of Patients and Family Members with Resistance to Local Anesthetics


About this study

The purpose of this study is to:

  1. To describe the clinical presentation of patients with resistance to local anesthetics.

  2. To consent subject for a blood draw and send the sample to local BAP core facility for DNA isolation.

  3. To send the DNA sample to the Sequencing Core at Mayo Rochester to sequence the participants’ exome including the sodium channel genes.

  4. Analyze the patient’s and family members’ whole exome sequence to identify novel mutations associated with the patient’s clinical presentation.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Patients identified with local anesthesia resistance and related family members.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Michael Ackerman, M.D., Ph.D.

Open for enrollment

Contact information:

Carla Haglund-Turnquist

(507) 284-8900

More information


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