A Study to Evaluate Improving PET Image Quality and Quantification by Using Motion Correction, Parametric Imaging and MAP Reconstruction


About this study

The aims of this research project are to assess the effectiveness of motion correction software for patients undergoing PET brain scans, to assess the data acquisition and image processing workflow for parametric analysis of brain and whole body scans, and to assess the quality of PET images reconstructed with maximum a posteriori (MAP) reconstruction algorithm.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • 18 years of age or older.
  • Subjects who are able and willing to sign the informed consent.
  • Subjects who are able to follow verbal commands.
  • A negative urine pregnancy test within 48 hours prior to PET imaging procedures in females of childbearing potential.
  • Subjects who are scheduled for a PET/CT study under Mayo Clinic Rochester IRB research protocol 08-005553 (Aim 1 cohort only).
  • A positive 18F-FDG oncology PET/CT exam in the last six months (Aim 2 cohort only).

Exclusion Criteria:

  • Patients who are unable to lay still for an additional 15 minutes (for Aim 1 cohort).
  • Patients who are unable to lay still for 90 min for 18F-FDG scans or 100 min for 18F-AV1451 scans (for Aim 2 cohort).
  • Patients who cannot follow the prep instructions.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Bradley Kemp, Ph.D.

Open for enrollment

Contact information:

Kurt Kevin Degillo CCRP

(507) 422-5407


More information


Publications are currently not available

Mayo Clinic Footer