A Study to Evaluate Endoscopic Endonasal Skull Base Surgery and Pituitary Surgery Quality of Life


About this study

The objectives of this study are to:

    • Measure the short and long-term overall and nasal-specific quality of life (QOL) impact of patients undergoing Endoscopic Endonasal Skull Base Surgery (EESBS) for pituitary and sellar lesions.
    • Determine the relative difference in QOL impact of EESBS for patients undergoing surgery for functional and nonfunctional pituitary adenomas.
    • Generate baseline data to development and validate a site-specific endoscopic-specific comprehensive QOL for EESBS.
    • Particular tumors of interest include pituitary tumors, Rathke’s cleft cysts, craniopharyngiomas, clival chordomas and chondrosarcomas.
    • Specific QOL aims focus on olfaction (sense of smell), gustation (sense of taste) and nasal function.



Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Patients with a pituitary/sellar lesion undergoing endoscopic endonasal resection.

Exclusion Criteria:

  • Patients undergoing open non-endoscopic approaches to their pituitary/sellar lesion.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Garret Choby, M.D.

Open for enrollment

Contact information:

Marissa Larson

(507) 216-4999


More information


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