Clinical Trials

Key Inclusion Criteria:

1. Patients with confirmed COVID19 infection or suspected COVID19 infection
2. Patients requiring high-flow nasal cannula (HFNC) or non-invasive positive pressure ventilation (NIPPV)
3. Patients who are clinically stable and able to tolerate the changes in position that are routinely conducted as part of the standard of care in the medical ICU
4. Patient/responsible family member signing the informed consent must speak English
5. Able to actively participate in Assisted Manual Pronation Therapy per nursing assessment
    
   Exclusion Criteria: 
    
   Contraindication for prone positioning:

1. Intracranial pressure >30 mm Hg or cerebral perfusion pressure <60 mmHg
2. Massive hemoptysis requiring an immediate surgical or interventional radiology procedure
3. Tracheal surgery or sternotomy during the previous 15 days
4. Serious facial trauma or facial surgery during the previous 15 days
5. Deep venous thrombosis treated for less than 2 days
6. Cardiac pacemaker inserted in the last 2 days
7. Unstable spine, femur, or pelvic fractures
8. Hemodynamic instability or severe cardiac arrhythmia (chronic AFib is not a contraindication). Mean arterial pressure lower than 60 mm Hg, >1 vasopressor agent or Norepinephrine equivalent dose >0.06 mcg/kg/min
9. Pregnant women
10. Single anterior chest tube with air leaks
11. Burns on more than 20 % of the body surface
12. Delirium or altered mental status increasing fall risk while in prone position.
13. End-of-life decision before inclusion
14. Subject deprived of freedom, minor, subject under a legal protective measure
15. Opposition from next of kin
16. Unable to actively participate in Assisted Manual Pronation Therapy per nursing assessment