A Study to Evaluate Resting State Connectivity in Adolescents with Postural Orthostatic Tachycardia Syndrome and Chronic Pain

Overview

About this study

The purposes of this study are to compare the functional connectivity in adolescent patients with Postural Orthostatic Tachycardia Syndrome (POTS) both with and without chronic pain, to those with chronic pain alone, to that of healthy controls; to evaluate whether there is a change in functional connectivity following participation in an intensive rehabilitation-oriented program previously demonstrated to have excellent outcomes with regard to functional recovery and symptom control; and to correlate outcomes using standardized symptom and function rating scales to imaging findings.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:  Group # 1 (ONLY POTS):

  • Adolescents between ages of 13 and 18 years.
  • Patients will complete the three week Pediatric Pain Rehabilitation Center program.
  • POTS will be identified on the basis of accepted criteria (chronic symptoms of orthostatic intolerance, with heart rate increase of greater than 40 beats per minute or more with head up tilt, in the absence of orthostatic hypotension).
  • For this study, the diagnosis will have been made on the basis of autonomic reflex screening performed at Mayo Clinic.
  • No-Chronic pain. Chronic pain is identified as pain lasting more than 12 weeks; at the point of referral to the PPRC, pain is identified as causing functional impairment. 
  • Patients will have the ability to assent for the participation in the research study.

Exclusion Criteria: 

  • Documented disability including developmental delay, cognitive disability, blindness, deafness, paralysis, or psychosis.
  • Metal implants, such as pacemakers or braces
  • Women cannot be pregnant or breastfeeding.
  • Patients will be excluded if they do not complete the three week PPRC program.

Inclusion Criteria: Group # 2 (POTS and Chronic Pain):

  • Adolescents between ages of 13 and 18 years.
  • Patients will complete the three week Pediatric Pain Rehabilitation Center program.
  • POTS will be identified on the basis of accepted criteria (chronic symptoms of orthostatic intolerance, with heart rate increase of greater than 40 beats per minute or more with head up tilt, in the absence of orthostatic hypotension). For this study, the diagnosis will have been made on the basis of autonomic reflex screening performed at Mayo Clinic.
  • Chronic pain is identified as pain lasting more than 12 weeks; at the point of referral to the PPRC, pain is identified as causing functional impairment. 
  • Patients will have the ability to assent for the participation in the research study.

Exclusion Criteria: 

  • Documented disability including developmental delay, cognitive disability, blindness, deafness, paralysis, or psychosis.
  • Metal implants, such as pacemakers or braces
  • Women cannot be pregnant or breastfeeding.
  • Patients will be excluded if they do not complete the three week PPRC program.

Inclusion Criteria: Group # 3 (Chronic Pain Alone):

  • Adolescents between ages of 13 and 18 years.
  • Patients will complete the three week Pediatric Pain Rehabilitation center Program
  • No POTS diagnosis.
  • Chronic pain is identified as pain lasting more than 12 weeks at the point of referral to the PPRC; pain is identified as causing functional impairment.
  • Patients will have the ability to assent for the participation in the research study.

Exclusion Criteria: 

  • Documented disability including developmental delay, cognitive disability, blindness, deafness, paralysis, or psychosis.
  • Metal implants, such as pacemakers or braces.
  • Women cannot be pregnant or breastfeeding.
  • Patients will be excluded if they do not complete the three week pediatric Pain Rehabilitation Center Program.

Inclusion Criteria: Control Group

  • Adolescents between ages of 13 and 18 years.
  • Patients will have the ability to assent for the participation in the research study.

Exclusion Criteria:

  • Documented disability including developmental delay, cognitive disability, blindness, deafness, paralysis, or psychosis.
  • Metal implants, such as pacemakers or braces.
  • Women cannot be pregnant or breastfeeding.
  • Any active acute or chronic medical condition.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Philip Fischer, M.D.

Open for enrollment

Contact information:

Supriya Behl B.S.

(507)538-1440

Behl.Supriya@mayo.edu

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available

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CLS-20485247

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