A Study to Evaluate the Effectiveness of Antihistamines in the Treatment of Eosinophilic Esophagitis


About this study

The purpose of this study is to assess the effectiveness of antihistamines in the treatment of eosinophilic esophagitis.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Patients over the age of 18.
  • Male or female patients.
  • Patients who carry the diagnosis of EoE based on esophageal biopsies obtained within 6 months prior to enrollment (>15 eosinophils per hpf on at least 2 esophageal levels).
  • Subjects must be able to give appropriate informed consent.

Exclusion Criteria

  • Not willing or able to sign consent.
  • Patients who have used topical or systemic corticosteroid therapy for any reason in the previous 6 weeks.
  • Patients who have been treated with acid-suppressing medications (PPI or H2 receptor antagonists) in the previous 6 weeks.
  • Patients on immunosuppressive or immunomodulating medications in the previous 6 weeks.
  • Patients with known allergies or hypersensitivity to anti-histamines.
  • Patients who have contraindications to the procurement of biopsies including patients who have known bleeding disorders, a history of bleeding diathesis, or who are currently using warfarin or clopidogrel.
  • Patients who have a contraindication to the performance of an esophagogastroduodenoscopy (EGD) including previous cardiopulmonary arrest during an endoscopic procedure.
  • Patients who are pregnant.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Jacksonville, Fla.

Mayo Clinic principal investigator

Dawn Francis, M.D.

Closed for enrollment

More information


Publications are currently not available

Mayo Clinic Footer