A Study to Evaluate Prevalence of Secondary Adrenal Insufficiency in Patients with Chronic Pain


About this study

The purpose of this study is to evaluate the hormonal profile related to opioed induced adrenal insufficency (OIAI) in chronic pain patients that completed the 3-weeks Interdisciplinary Pain Rehabilitaion Program (IPRP) at the Pain Rehabilitation Center (PRC) at Mayo Clinic / Florida.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

  1. Adults females and males older than 18 years-old
  2. Patients taking opioid medications or other  analgesics for at least 3 months prior to enrollment in IPRP
  3. Patients who successfully complete the 3-weeks IPRP
  4. Patients who successfully  discontinue use of opiate medications during IPRP
  5. Patients who have signed study consent


Exclusion criteria

  1. Subjects that do not complete the IPRP
  2. Subjects under any type of glucocorticoid treatment (oral, inhaled, intra-articular or topical)
  3. Subjects with existing  diagnosis of adrenal insufficiency or hypogonadism
  4. Immunocompromised patients
  5. Patients with current pregnancy
  6. Patients with current hormonal therapy/ replacement
  7. Subjects who have undergone surgical intervention within 30 days prior to enrollment in IPRP
  8. Subject with a history of cancer requiring active treatment in the last 6 months

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Jacksonville, Fla.

Mayo Clinic principal investigator

Mark Friedrich Hurdle, M.D.

Contact us for the latest status

Contact information:

Erica Cook Ph.D.



More information


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