A Study to Evaluate the Response of Dietary Therapy in Eosinophilic Esophagitis (EoE)


About this study

The purpose of this study is to investigate the response rate of dietary therapy in patients with Eosinophilic Esophagitis (EoE) and determine rates of long-term compliance with the food elimination diets (SFED, FFED, step-up), and also to identify patient, clinical, and endoscopic factors that may be associated with increased rates of success in patients undergoing dietary therapy in EoE.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Patients 18 years old and older.
  • Patients must have been diagnosed with EoE (shown to have symptoms of dysphagia or food impaction with >15 eosinophils per high powered field on esophageal biopsy).
  • Patients must have undergone the same elimination dietary therapy (i.e., empiric six food elimination dietary therapy) and have initial endoscopy with available histopathology with subsequent endoscopic follow-up at Mayo Clinic, Rochester between January 2012 and January 2019.
  • Pre- and post- dietary therapy histopathology must be available for comparison.
  • Patients with PPI-REE will be treated as EoE.

Exclusion Criteria: 

  • Patients with other causes of dysphagia or food impaction (i.e., achalasia, malignancy, etc.).
  • Patients less than 18 years old.
  • Patients lost to follow-up.
  • Patients who choose not to participate in the phone questionnaire.


Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Jeffrey Alexander, M.D.

Contact us for the latest status

Contact information:

Crystal Lavey CCRP



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