A Study to Understand Serum Biotin Clearance as a Means to Mitigate the Risk of Biotin Interference with Clinical Laboratory Tests

Overview

About this study

The purpose of this study is to determine the clearance rate of biotin from the serum in patients with impaired renal function following ingestion of over-the-counter biotin supplements.

 

 

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Healthy subjects: apparently normal health with suspected eGFR >90 (will be confirmed at baseline testing), willing and able to participate in complete study duration.
  • Patients with renal impairment: eGFR reported in the EMR within the last 60 days 15-59 mL/min/1.73 m­­­2 with diagnosis of chronic kidney disease.

Exclusion Criteria:

  • Healthy subjects:  
    • weigh less than 110 lbs;
    • known kidney dysfunction;
    • hypertension;
    • diabetes;
    • pregnant;
    • breast-feeding mother;
    • intolerance to biotin, currently taking or have taken biotin or biotin-containing;
    • supplements within the last 30 days.
  • Patients with renal impairment: weigh less than 110 lbs, patients on dialysis, pregnant, breast-feeding.
  • mother, intolerance to biotin, currently taking or have taken biotin or biotin-containing supplements within the last 30 days.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Brooke Katzman, Ph.D.

Open for enrollment

Contact information:

Mohamed Ibrahim

(507)284-4115

Ibrahim.Mohamed@mayo.edu

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available

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CLS-20473766

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