A Study to Analyze Normal Values to Measure Human Small Intestinal and Colonic Permeability


About this study

The primary purpose of this study is to obtain normative data (median, 10th and 90th percentile), as well as inter-individual coefficient of variation (COV, assessed by [SD/mean]) with approximately 15 participants in each age group: 18-30, 31-45, 46-60, and 60-70 years old.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Healthy, non-obese participants.
  • Non-pregnant Caucasian volunteers.
  • 18-70 years old.
  • Male or female, 1:1.
  • BMI < 30kg/m2.

Exclusion Criteria:

  • Diabetes.
  • Hypertension.
  • BMI ≥ 30kg/m^2.
  • Chronic NSAID use (> 3 days/week).



Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Michael Camilleri, M.D.

Closed for enrollment

More information


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