Characterizing Heart Changes Related to Chemo-Radiotherapy


About this study

The purpose of this study is to determine the 12-month cardiac event rate  after radiation or chemo-radiation for the treatment of lung or esophageal cancer.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  1. Age ≥ 18 years.
  2. Planned standard of care curative thoracic RT or CRT with anticipated heart V40 > 20cc (At least 20cc of the heart should receive a dose of 40Gy or higher).
  3. Able to follow-up at all specified standard of care time-points.
  4. Patients can receive treatment as part of the standard of care or in a different study. 


Exclusion Criteria:

  1. Metastatic disease.
  2. Recurrent disease.
  3. Patient receiving radiation prescription doses lower than 40 Gy. 

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Carlos Vargas, M.D.

Closed for enrollment

Contact information:

Cancer Center Clinical Trials Referral Office

(855) 776-0015

More information


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