A Study to Assess Opioid-Induced Respiratory Depression Using Diaphragm Muscle Shear Wave Elastography


About this study

The purpose of this study is to determine the impact of opioid administration on diaphragm muscle forces during resting breathing and during higher force maneuvers by using a non-invasive shear wave elastography (SWE) method.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Adult male and non-pregnant women 18 years old or older.
  • Subject is able to understand the study procedure and provide informed consent.

Exclusion Criteria: 

  • Subject is pregnant or breast feeding.
  • Patient pregnancy status will be obtained through standard of care at Mayo Clinic per Pre-Procedure Pregnancy Reasonably Excluded Guide (PREG) protocol: http://mayoweb.mayo.edu/sp-forms/mc2700-mc2799/mc2722-13.pdf.
  • Subject is unable to provide informed consent.
  • Subject has a pre-existing respiratory condition.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Carlos Mantilla, M.D., Ph.D.

Open for enrollment

Contact information:

Carlos Mantilla M.D., Ph.D.



More information


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