A Study to Compare Anticoagulation with Left Atrial Appendage Closure after AF Ablation

Overview

  • Study type

    Interventional
  • Study IDs

  • Describes the nature of a clinical study. Types include:

    • Observational study — observes people and measures outcomes without affecting results.
    • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
    • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
  • Site IRB
    • Rochester, Minnesota: 19-001742
    NCT ID: NCT03795298
    Sponsor Protocol Number: S2239

About this study

The primary objective of this study is to determine if left atrial appendage closure with the WATCHMAN FLX Device is a reasonable alternative to oral anticoagulation following percutaneous catheter ablation for high risk patients with non-valvular atrial fibrillation.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

See eligibility criteria

Inclusion Criteria:

  • The subject is of legal age to participate in the study per the laws of their respective geography. 
  • Underwent a prior catheter ablation procedure for non-valvular AF between 90 and 180 days prior to randomization (sequential) or is planning to have clinically indicated catheter ablation within 10 days of randomization (concomitant). 
  • The subject has a calculated CHA2DS2-VASc score of 2 or greater for males or 3 or greater for females. 
  • The subject is deemed to be suitable for the defined protocol pharmacologic regimen. 
  • The subject is able to undergo TEE examinations. 
  • The subject or legal representative is able to understand and is willing to provide written informed consent to participate in the trial. 
  • The subject is able and willing to return for required follow-up visits and examinations.

Exclusion Criteria: 

  • The subject is currently enrolled in another investigational study that would directly interfere with the current study, except when the subject is participating in a mandatory governmental registry, or a purely observational registry with no associated treatments. Each instance must be brought to the attention of the sponsor to determine eligibility, regardless of type of co-enrollment being proposed. 
  • The subject requires long-term anticoagulation therapy for reasons other than AF-related stroke risk reduction, for example due to an underlying hypercoagulable state (i.e., even if the device is implanted, the subjects would not be eligible to discontinue OAC due to other medical conditions requiring chronic OAC therapy). 
  • The subject is deemed by the treating physician to be unsuitable for chronic anticoagulation and/or aspirin therapy due to bleeding risk, allergy, or other reasons. 
  • The subject had or is planning to have any cardiac or major non-cardiac interventional or surgical procedure (excluding non-valvular AF ablation and cardioversion) within 30 days prior to or 60 days after randomization [including, but not limited to: percutaneous coronary intervention (PCI), other cardiac ablation (VT ablation, etc.), etc.]. 
  • The subject had a stroke or transient ischemic attack (TIA) within the 60 days prior to randomization. 
  • The subject had a prior major bleeding event per ISTH definition within the 14 days prior to randomization. Lack of resolution of related clinical sequelae, or planned and pending interventions to resolve bleeding/bleeding source, are a further exclusion regardless of timing of the bleeding event. 
  • The subject has had a myocardial infarction (MI) documented in the clinical record as either a non-ST elevation MI (NSTEMI) or as an ST-elevation MI (STEMI), with or without intervention, within 90 days prior to randomization.
  • The subject has a history of atrial septal repair or has an ASD/PFO device. 
  • The subject has an implanted mechanical valve prosthesis in any position. 
  • The subject is of childbearing potential and is, or plans to become pregnant during the time of the study (method of assessment upon study physician's discretion).
  • The subject has a documented life expectancy of less than two years.
  • The subject has a cardiac tumor. 
  • The subject has signs/symptoms of acute or chronic pericarditis. 
  • There is evidence of tamponade physiology. 
  • Contraindications (anatomical or medical) to percutaneous catheterization procedures. 
  • The subject has documented NYHA Class IV heart failure. 
  • The subject has documented surgical closure of the left atrial appendage. 
  • The subject has an active infection.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Douglas Packer, M.D.

Contact us for the latest status

Contact information:

Laura Peterson

7757456

Peterson.Laura@mayo.edu

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available

.
CLS-20467340

Mayo Clinic Footer