A Study to Evaluate Cardiopulmonary Complications in Systemic Sclerosis

Overview

About this study

The purpose of this study is to assess whether our not the percentage of pulmonary related vascular structures (PRVS) determined by the quantitative CT (Q-CT) tool CALIPER is a novel measure that can be used for the early detection of pulmonary vascular remodeling in patients with SSc.  pulmonary related vascular structures

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Please contact the study team to discuss whether or not you are eligible to participate in a study.

Inclusion Criteria:

  • All adult (18+ years of age).
  • 1980 or 2013 American College of Rheumatology (ACR) Systemic Sclerosis Classification Criteria,12,13 2) at least 3 of the 5 features of CREST (calcinosis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, telangiectasias) syndrome.
  • The combination of definite Raynaud’s phenomenon, abnormal nailfold capillaries, and a SSc specific autoantibody (anti-centromere, anti-topoisomerase I/Scl70, or anti-RNA polymerase III). Prior work suggests that approximately 80% of patients retrieved from the institution’s database with a diagnosis code for scleroderma meet 2013 classification criteria.14

Exclusion Criteria: 

  • CT scans will be excluded if contrast was utilized.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Alicia Hinze, M.D.

Contact us for the latest status

Contact information:

Alicia Hinze M.D.

127or7724586

Hinze.Alicia@mayo.edu

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

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CLS-20467335

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