A Study to Evaluate Cardiopulmonary Complications in Systemic Sclerosis


About this study

The purpose of this study is to assess whether our not the percentage of pulmonary related vascular structures (PRVS) determined by the quantitative CT (Q-CT) tool CALIPER is a novel measure that can be used for the early detection of pulmonary vascular remodeling in patients with SSc.  pulmonary related vascular structures

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • All adult (18+ years of age).
  • 1980 or 2013 American College of Rheumatology (ACR) Systemic Sclerosis Classification Criteria,12,13 2) at least 3 of the 5 features of CREST (calcinosis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, telangiectasias) syndrome.
  • The combination of definite Raynaud’s phenomenon, abnormal nailfold capillaries, and a SSc specific autoantibody (anti-centromere, anti-topoisomerase I/Scl70, or anti-RNA polymerase III). Prior work suggests that approximately 80% of patients retrieved from the institution’s database with a diagnosis code for scleroderma meet 2013 classification criteria.14
  • Control (comparator) population will be patients underwent a non-contrast chest CT scan after 2007 for non-pulmonary indictions

Exclusion Criteria: 

  • CT scans will be excluded if contrast was utilized.
  • CT scans will be excluded if there are pulmonary effusions for masses which would affect the CALIPER results.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Alicia Hinze, M.D., M.H.S.

Contact us for the latest status

Contact information:

Alicia Hinze M.D., M.H.S.

(507) 422-4586


More information


Publications are currently not available

Mayo Clinic Footer