A Study to Measure Markers of Immune Tolerance to Predict Women at Risk of Miscarriage or Failed Embryo Transfer

Overview

About this study

The purpose of this study is: 

Infertility Cohort - To determine if maternal blood concentrations of Gal-9, IL-4, and VEGF-A, -C, -D at the time of embryo transfer in patients undergoing in vitro fertilization are predictive of the cycle outcome: live birth or no live birth

Spontaneous Conception Cohort - To determine if maternal blood concentrations of Gal-9, IL-4, and VEGF-A, -C, -D early in the first trimester of gestation are predictive of miscarriage or live birth.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria - Infertility Cohort

  • Adult females undergoing a euploid frozen embryo transfer.
  • Women age 18 years of age or older.
  • Must be planning to have all blood work done at Mayo Clinic Rochester so we can receive the study samples.
  • Must be planning to deliver within the Mayo Clinic Health System so that we can review pregnancy outcomes.

Exclusion Criteria - Infertility Cohort: 

  • Non English speaking.
  • Less than 18 years of age.
  • Planning follow-up outside Mayo Clinic Rochester/MCHS.
  • Pregnancies with multiple fetuses.

Inclusion Criteria - Spontaneous Conception Cohort

  • Adult women presenting with positive pregnancy test to the Obstetrics Department.
  • Women age 18 years of age or older.
  • Confirmed intrauterine pregnancy (defined as gestational sac with yolk sac +/- fetal pole).
  • Patients need to be planning to deliver within the Mayo Clinic Health System so that we can review pregnancy outcomes.

Exclusion Criteria - Spontaneous Conception Cohort: 

  • Non English speaking.
  • Less than 18 years of age.
  • Planning follow-up outside Mayo Clinic Rochester/MCHS.
  • Patients desiring termination of pregnancy.
  • Known miscarriage at the time of recruitment.
  • Pregnancies with multiples.

 

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Chandra Shenoy, M.D.

Open for enrollment

Contact information:

Chelsie VanOort

(507)266-9642

VanOort.Chelsie@mayo.edu

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available

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CLS-20467310

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