Laser Therapy for Survivors of Gynecological Cancer


About this study

This randomized pilot trial studies how well fractional carbon dioxide (CO2) laser therapy works in minimizing genitourinary syndrome of menopause (GSM) in gynecological cancer survivors. Fractional CO2 laser therapy may reduce symptoms of GSM in survivors of gynecologic cancers.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Women with cervical, endometrial, vaginal, vulvar or ovarian cancer who have completed all cancer related treatment ≥ 6 months prior to enrollment.
  • Any form of hysterectomy, including radical hysterectomy permitted.
  • Must have no evidence of recurrent disease on pelvic exam within past 3 months.
  • Radiation therapy is permitted but not required.
  • Patient reported dyspareunia and/or vaginal dryness with severity of ≥ 4 on a scale from 0 (none) to 10 (most severe) that has been persistent over ≥ 4 weeks and/or the inability to be sexually active due to pain.

Exclusion Criteria:

  • Patients with recurrent or metastatic endometrial, vaginal, vulvar, cervical, or ovarian cancer.
  • Pelvic organ prolapse stage II or higher.
  • Prior reconstructive pelvic surgery involving mesh.
  • Hormone replacement therapy or vaginal estrogen therapy within 6 weeks prior to enrollment.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Stephanie Faubion, M.D.

Contact us for the latest status

Contact information:

Cancer Center Clinical Trials Referral Office


More information


Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

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