A Study to Evaluate the Effect of Fasting Free Fatty Acids and Fasting Glucose on Postprandial Glucose Metabolism


About this study

The purpose of this study is to determine if changes in fasting glucose and fasting free fatty acids (FFA) concentrations alter postprandial glucose metabolism in non-diabetic and pre-diabetic humans.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Will utilize the Mayo Clinic Biobank to identify randomly- selected individuals encompassing the age span of 25-65 years old.
  • No history of diabetes.
  • Reside within a 100 mile radius of Mayo Clinic, Rochester, MN.
  • Individuals who have expressed interest in participating in research will then be contacted and invited to participate in the study.

Exclusion Criteria:

  • Age < 25 or > 65 years old (to avoid studying subjects who could have latent type 1 diabetes or the effects of age extremes in subjects with normal or impaired fasting glucose).
  • HbA1c ≥ 6.5%.
  • Use of glucose-lowering agents.
  • For female subjects, positive pregnancy test at the time of enrollment or study.
  • History of prior upper abdominal surgery such as adjustable gastric banding, pyloroplasty and vagotomy.
  • Active systemic illness or malignancy.
  • Symptomatic macrovascular or microvascular disease.
  • Hormone therapy >0.625 mg premarin daily.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Adrian Vella, M.D.

Closed for enrollment

More information


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