A Time Study of the Microbiome in Colorectal Cancer Subjects


About this study

The purposes of this study are to characterize the microbes that are causal of colorectal cancer and those that are merely conditions of the tumor. This will be accomplished by comparing the microbiomes before and after resection.  Secondly, to pilot a study to differentiate between the effect of resection versus the effect of tumor removal by comparing microbiomes in two cohorts: colorectal cancer patients and controls from benign colon resection.  Finally, to understand what confers community-level microbial stability or resilience in a colorectal cancer patient. This pilot study will be accomplished by sampling stool samples from patients longitudinally, and then using advance bioinformatics and statistical learning techniques to identify features predictive of gut microbial ecological properties.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • 18 years of age or older.
  • Patients undergoing bowel resection by any standard surgical approach.
  • Patients with colorectal cancer
  • Patients without colorectal cancer.

Exclusion Criteria:

  • Undergoing a complete proctectomy.
  • Have a tentative diagnosis of GIST or carcinoid.
  • Females that are pregnant.
  • Currently receiving or have received pelvic cancer radiation therapy in the past 2 weeks.
  • Currently receiving or have received chemotherapy in the past 2 weeks.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Nicholas Chia, Ph.D.

Contact us for the latest status

Contact information:

Jennifer Martin



More information


Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

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