A Study of the Biological System of Allergic Fungal Sinusitis Mucin


About this study

The purpose of this study is to describe the proteome of mucus in patients without chronic rhinosinusitis (nCRS) with an emphasis on cytokines and bone morphogenic proteins present (BMPs), to describe the proteome of mucus in patients with chronic rhinosinusitis without polyps (CRSsNP) with an emphasis on cytokines and BMPs present, to describe the proteome of mucus in patients with allergic fungal sinusitis (AFRS) with an emphasis on cytokines and BMPs present, and to identify BMPs differentially elevated in patients with AFRS compared to patients with nCRS or CRS.


Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Adults 18 years and older.
  • Scheduled for surgery.
  • Patients undergoing sinus surgeries for CRSsNP will also be recruited as CRS controls.
  • Subjects without sinusitis undergoing sinus surgery for access to the pituitary will also be recruited as negative controls.
  • Subjects with hormonal diseases (e.g., Cushing’s disease) and coagulopathies will be excluded.
  • Only patients going to surgery for clinical management will be recruited – no surgery is performed to collect samples only.

Exclusion Criteria:

  • Patients with asthma, autoimmune diseases and aspirin sensitivity will be excluded from the controls.    


Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Jacksonville, Fla.

Mayo Clinic principal investigator

Osarenoma Olomu, M.D.

Open for enrollment

Contact information:

Carolyne Stevens



More information


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