A Study of Cardiopulmonary Exercise Heart Sound S1

Overview

About this study

The purpose of this study is to evaluate the ability to determine the first heart sound (S1) and its relationship to aerobic capacity.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Cohort A

  • Subjects without diagnosis of cardiovascular disease, including coronary artery disease, myocardial infarction and heart failure.
  • Age 18 years or older on the day of screening.
  • Agreeable to wear the WCD.

Cohort B

  • Subjects with history of heart failure and at least one prevoius heart failure hospitalization.
  • Age 18 years or older on the day of screening.
  • Agreeable to wear the WCD.

Exclusion Criteria:

Absolute Contraindication to Exercise Testing

  • Acute myocardial infarction (within 2 days).
  • Unstable angina not previously stabilized by medical therapy.
  • Uncontrolled cardiac arrhythmias causing symptoms or hemodynamic compromise.
  • Symptomatic severe aortic stenosis.
  • Uncontrolled symptomatic heart failure.
  • Acute pulmonary embolus or pulmonary infarction.
  • Acute myocarditis or pericarditis.
  • Acute aortic dissection.

Relative Contraindication to Exercise Testing

  • Left main coronary stenosis.
  • Moderate stenotic valvuar heart disease.
  • Electrolyte abnormalities.
  • Severe arterial hypertension.
  • Tachyarrhythmias or bradyarrhythmias.
  • Hypertrophic cardiomyopathy and other forms of outflow tract obstruction.
  • Mental or physical impairment leading to inability to exercise adequately.
  • High-degree atrioventricular block.
  • Advance or complicated pregnancy.

Other Reasons for Exclusion

  • Subjects with a pacemaker dependent rhythm, including implanted pacemaker or CRT.
  • Subjects having a chest circumference over 56 inches (142 cm) or under 26 inches (66 cm).
  • Subjects unable or unwilling to provide informed consent.

 

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Bruce Johnson, Ph.D.

Closed for enrollment

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available

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CLS-20454330

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