A Study to Evaluate The Effect of Transgender Hormone Therapy on Adipose Tissue Biology and Distribution

Overview

About this study

The purpose of this study is to determine if cardiometabolic risk correlates with the estradiol (E) to testosterone (T) ratio or circulating concentrations, cross sex hormone duration or route, and to determine if changes in the E/T ratio are associated with changes in insulin sensitivity, body composition and adipose tissue fatty acid metabolism in transgender women.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Transgender individuals with gender dysphoria as diagnosed by a mental health provider by WPATH standards of care (version 7). 
  • Stable mental health with mild or negative screening tools for depression and anxiety are required as monitored by behavioral health providers in the Mayo TISCC on
    • stable cross sex hormones; or
    • before and after initiation of cross sex hormones; or
    • before and after gender-affirming gonadectomy.

Exclusion Criteria:

  • As noted above, participants will be excluded if they do not have stable mental health as assessed by our mental health providers along with any elevated screening tools for depression or anxiety.
  • Participants cannot be pregnant. 

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Alice Chang, M.D.

Open for enrollment

Contact information:

Department of Medicine - Clinical Trials Unit

(507) 266-1944

RSTDOMCTU@mayo.edu

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available

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CLS-20454329

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