A Study of Factors That Predispose, Promote, and Perpetuate Post-Traumatic Dizziness


About this study

The purpose of this study is to investigate whether recent, groundbreaking discoveries about key pathophysiologic processes that drive chronic dizziness in patients without traumatic brain injury (TBI9,10) are applicable to patients with post-mTBI vestibular disability. We expect the results of this project to have practical clinical and research applications, providing novel data for two future steps:

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Men and women, age 18-60 years old.
  • Right-hand dominated.
  • Vestibular symptoms of moderate or greater severityb after a verified mTBI:
    • Vertigo, unsteadiness, dizziness, or gait imbalance;
    • Possible or Probable TBI per per Mayo TBI Severity Classification System.

Exclusion Criteria:

  • Medical or psychiatric conditions, medications, or substances that would limit a participant’s ability to provide consent or complete all study procedures
    • (NOTE: By definition, alterations in mental state may not persist for more than 24 hours in patients diagnosed with a mTBI.  Therefore, patients with persistent cognitive impairment of any degree of severity will be ineligible to participate in this study.)
  • Metal in the body that is not compatible with MRI.
  • Active tobacco usage.
  • Pregnant or breast-feeding.
  • Any history of major neurologic, otologic, or psychiatric disorders,d pre-dating injury
  • Any history of major neurologic, otologic, or psychiatric disorders.
  • Past history of Probable or Definite TBI or TBI associated with structural  vestibular injury.
  • Any history of symptomatic TBIPast history of Probable or Definite TBI or TBI associated with structural  vestibular injury.
  • Changes in neurologic or psychiatric medications within 2 weeks of fMRI.
  • Use of neurological or psychiatric medications.

Eligibility last updated 7/3/23. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Jeffrey Staab, M.D.

Open for enrollment

Contact information:

Deanna Hofschulte CCRP

(507) 255-2972


More information


Publications are currently not available

Mayo Clinic Footer