A Study of Factors That Predispose, Promote, and Perpetuate Post-Traumatic Dizziness

Overview

About this study

The purpose of this study is to investigate whether recent, groundbreaking discoveries about key pathophysiologic processes that drive chronic dizziness in patients without traumatic brain injury (TBI9,10) are applicable to patients with post-mTBI vestibular disability. We expect the results of this project to have practical clinical and research applications, providing novel data for two future steps:

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Please contact the study team to discuss whether or not you are eligible to participate in a study.

Inclusion Criteria:

  • Men and women, age 18-50 years old.
  • Right-hand dominated.
  • Vestibular symptoms of moderate or greater severityb after a verified mTBI:
    • Vertigo, unsteadiness, dizziness, or gait imbalance;
    • mTBI per Table 1 of the VA/DoD mTBI guideline;
    • Enrolled within 8 weeks of mTBI (Rochester, London);
    • Enrolled within 6 months of mTBI (Rome).

Exclusion Criteria:

  • Medical or psychiatric conditions, medications, or substances that would limit a participant’s ability to provide consent or complete all study procedures
  • Metal in the body that is not compatible with MRI.
  • Active tobacco usage.
  • Pregnant or breast-feeding.
  • Neurologic, otologic, or psychiatric disorders, pre-dating injury.
  • Any history of neurologic, otologic, or psychiatric disorders.
  • Any history of symptomatic TBI.
  • Changes in neurologic or psychiatric medications within 2 weeks of fMRI.
  • Use of neurological or psychiatric medications.

 

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Jeffrey Staab, M.D.

Open for enrollment

Contact information:

Michelle Skime M.S., CCRP

(507)255-0501

Skime.Michelle@mayo.edu

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available

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CLS-20449554

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