Study of Immunotherapy and Ovarian Function Among Premenopausal Melanoma Survivors


About this study

The purpose of this study is to analyze the ovary function of female premenopausal melanoma survivors who have undergone immunotherapy, and to compare with data from age-matched controls.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Cohort 1:
    • Women, 40 years of age or under;
    • Diagnosed with melanoma (Stage III or above);
    • 1-5 years from diagnosis;
    • Either received immunotherapy with anti-PD1 agent (n=20); or
    • Received no immunotherapy (n=20).
  • Cohort 2:
    • Women, 40 years of age or under;
    • Diagnosed with melanoma;
    • Plan to undergo immunotherapy with anti-PD1 agent (n=20).

Exclusion Criteria: 

  • Women under 18 years of age.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Yiyi Yan, M.D., Ph.D.

Closed for enrollment

Contact information:

Cancer Center Clinical Trials Referral Office

(855) 776-0015

More information


Publications are currently not available

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