Study to Determine the Safety and Effectiveness of CLS-TA in Combination with an Intravitreal Anti-VEGF Agent in Subjects with Retinal Vein Occlusion

Overview

About this study

The purpose of this study is to demonstrate the safety and effectiveness of   CLS-TA ("suprachoroidal CLS-TA") used in combination with an anti-VEGF agent ("intravitreal anti-VEGF agent") in subjects with retinal vein occlusion (RVO).

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Please contact the study team to discuss whether or not you are eligible to participate in a study.

Inclusion Criteria:

  • Has a clinical diagnosis of RVO in the study eye.
  • Has a CST of ≥ 300 µm in the study eye.
  • Has an ETDRS BCVA score of ≥ 20 letters read and ≤ 70 letters read in the study eye.
  • Is naïve to local pharmacologic treatment for RVO in the study eye.

Exclusion Criteria:

  • Any active ocular disease or infection in the study eye other than RVO.
  • History of glaucoma, intraocular pressure > 21 mmHg or ocular hypertension requiring more than one medication.
  • Any uncontrolled systemic disease that, in the opinion of the Investigator, would preclude participation in the study.
  • Any evidence of neovascularization in the study eye.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Raymond Iezzi, M.D.

Open for enrollment

Contact information:

Daniel Hamiel

(507)538-4122

Hamiel.Daniel@mayo.edu

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available

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CLS-20442898

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