A Study to Determine the Impact of Ascorbic Acid Treatment on Vasodilation in Cardiac Surgery


About this study

The purpose of the study is to determine the feasibility of administration of high dose intravenous ascorbic acid in the operative and post-operative environments as well as sample size for a prospective, randomized, placebo controlled study.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Greater than 18 years of age.
  • Presenting for cardiac surgery at Mayo Clinic in Rochester, Minnesota.
  • Scheduled to undergo cardiac surgery with the use of cardiopulmonary bypass involving myectomy or valve replacement/repair.

Exclusion Criteria:

  • Cases involving planned coronary artery bypass grafting (CABG).
  • Cases requiring circulatory arrest.
  • Active infection or sepsis.
  • Severe hepatic disease or ascites.
  • Pre-operative renal dysfunction requiring dialysis.
  • Preoperative midodrine, oral steroid, or intravenous steroid use. Inhaled steroids are not an exclusion criteria.
  • Pregnancy and glucose-6-phosphate dehydrogenase (G6PD) deficiency.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Erica Wittwer, M.D., Ph.D.

Closed for enrollment

Contact information:

Laurie Meade R.N.

(507) 255-1829


More information


Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available


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