The Mayo Clinic Early Arthritis Cohort Study


About this study

The purpose of this study is to establish a cohort of clinical and biological samples of patients with early rheumatoid arthritis or arthritis like undifferentiated inflammatory arthritis in order to address multiple critical barriers that exist to improved outcomes for patients with RA and other chronic inflammatory arthritides, including: (1) gaps in understanding disease mechanisms; (2) the lack of highly useful diagnostic and prognostic tools; and (3) the unavailability of personalized, targeted therapies for patients with early inflammatory arthritis.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Age ≥18 years.
  • Diagnosis of RA fulfilling the ACR/EULAR 2010 classification criteria OR a diagnosis of UA suspected to be early RA with clinical synovitis of ≥1 joint and ≥1 other tender joint but not fulfilling classification criteria.
  • Disease duration ≤6 months.
  • Intention to start treatment with methotrexate (MTX).

Exclusion Criteria:

  • Personal history of another definite autoimmune or inflammatory rheumatic disease (e.g., systemic lupus erythematosus, polymyositis, dermatomyositis, vasculitis, gout, or CPPD) diagnosed by a rheumatologist, excluding secondary Sjogren’s syndrome.
  • Personal history of psoriasis diagnosed by a primary care physician or dermatologist.
  • Personal history of inflammatory bowel disease diagnosed by a gastroenterologist.
  • Unsuitability to participate in the judgment of a study investigator.
  • Unwillingness or inability to return to Mayo Clinic for research follow-up visits.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

John Davis, M.D.

Closed-enrolling by invitation

What is this? (?)
Not open to everyone who meets the eligibility criteria, but only those invited to participate by the study team.

Contact information:

Jane Jaquith C.C.R.C.

(507) 284-4502

More information


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