Obstructive Sleep Apnea and Chronic Cough


About this study

This study is designed to determine if there is an association between obstructive sleep apnea (OSA) and chronic cough, and if treatment of OSA with CPAP improves chronic cough.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Patients referred to the sleep center for PSG for suspected OSA


Exclusion Criteria:

  • Already on nocturnal positive pressure ventilation treatment;

  • Currently taking an ACE inhibitor;

  • Cigarette smoking within the last year;

  • Lung transplant recipients;

  • A history of, or current pulmonary cancer;

  • Any other active cancers requiring chemotherapy, or who are currently or previously have been treated with radiation therapy;

  • Prior lung surgery, or anticipated thoracic surgery in the next 90 days;

  • Currently on oxygen therapy other than for sleep apnea;

  • Currently being treated with narcotics;

  • Current or recent antibiotic treatment for a respiratory tract infection with 4 weeks;

  • Those who have started, stopped or had a recent change (>4 weeks) in dosage of a cough suppressant medication in the last four weeks (e.g. pregabalin, amitriptyline, or gabapentin), and is not expected to change during the course of the study, or the

  • Absence of faulty audio or visual recording per the routine clinical polysomnograpy.


Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Jacksonville, Fla.

Mayo Clinic principal investigator

Augustine Lee, M.D., M.S.

Closed-enrolling by invitation

What is this? (?)
Not open to everyone who meets the eligibility criteria, but only those invited to participate by the study team.

More information


Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available


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