A Study to Assess the Effect of Lower Hemoglobin Levels on Cardiac Functions in Patients with Cardiac Diseases


About this study

The purpose of this study is to test if a reduction of hemoglobin leads to subclinical cardiac dysfunction in patients with known cardiovascular disease.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:  

  1. Adult patients (≥18 years) undergoing coronary artery bypass surgery and/or aortic valve replacement surgery and aortic arch surgery.

Exclusion Criteria: 

  1. Presence of moderate to severe valvular disease other than aortic stenosis (stenosis or regurgitation)
  2. Presence of shock (SBP <90mmHg) or requirement of vasopressors or inotropes to support cardiac output or maintain systematic blood pressure
  3. Presence of severe left ventricular dysfunction (EF <35%)
  4. Mechanical circulatory support ( intra-aortic balloon pump, left ventricular assist device, impella)
  5. Patients with hearth rhythms other than sinus rhythm
  6. Presence of inflitrative cardiomyopathies.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

James Nelson, M.B.B.S.

Closed for enrollment

More information


Publications are currently not available

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