Brain and Cognition Effects of Cardio Resynchronization Therapy in Heart Failure

Overview

About this study

The purpose of this research study is to understand the effects of changes in the capability of the heart on brain function so that we can better predict who will most benefit from cardio-resynchronization therapy (CRT) and how it may enhance brain health.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria 

  1. Men and women 
  2. Age: 40-80 yrs 
  3. English speaking 
  4. Physically mobile (enough to get an MRI).

Exclusion Criteria 

  1. Prior significant neurological disorder (e.g., dementia, seizure disorder, moderate or severe traumatic brain injury) 
  2. We will exclude participants from analysis and further enrollment (follow-up visits) who reveal dementia based on NINDS-AIREN criteria
  3. Major psychiatric disturbance (e.g., schizophrenia, chronic intractable depression, substance abuse) 
  4. Evidence of major ischemic or hemorrhagic stroke
  5. Other unstable medical conditions (e.g. cancer; basal cell skin and limited prostate cancer are acceptable) 
  6. MRI contraindications (e.g., pregnancy, claustrophobia, metal implants, circumference > 60 inches, weight > 425 lbs) 
  7. Physical impairment precluding motor response or lying still for 1 hr.
  8. Use of medications known to influence cognitive functions (e.g., benzodiazepines, barbiturates, antipsychotics)
  9. Cardiac pacemaker dependence

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Jacksonville, Fla.

Mayo Clinic principal investigator

Erik Middlebrooks, M.D.

Closed for enrollment

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available

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CLS-20423518

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