Exercise to Treat Frailty in Kidney Transplant Candidates

Overview

  • Study type

    Interventional
  • Study IDs

  • Describes the nature of a clinical study. Types include:

    • Observational study — observes people and measures outcomes without affecting results.
    • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
    • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
  • Site IRB
    • Rochester, Minnesota: 17-009722
    NCT ID: NCT03535584
    Sponsor Protocol Number: 17-009722

About this study

Frailty is a condition characterized by slowness, weakness, low physical activity, wasting, and exhaustion. Frailty increases the risk for adverse outcomes following transplant such as increased length of stay in the hospital, mortality, or graft function. No interventions for frailty are known for patients with renal disease, but exercise programs like pulmonary rehabilitation have been effective in improving frailty in patients with other diseases, such as lung disease. The goal of this study is to test whether exercise will also improve frailty among patients who are waiting for a kidney transplant and who are considered frail or pre-frail.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

See eligibility criteria

Inclusion Criteria:

  • Aged 18 years or older.
  • Consenting to research.
  • CKD (stages 1-5).
  • An SPPB score ≤10 or considered frail or pre-frail by FP.

Exclusion Criteria:

  • Younger than 18 years of age.
  • Patients listed for heart or lung transplants.
  • Terminal illness with a prognosis of less than 6 months.
  • Significant comorbidities that limit rehabilitation potential including pulmonary disease requiring continuous oxygen supplementation, active angina, critical aortic sclerosis, decompensated heart failure, or known ventricular arrhythmia.
  • Kidney transplant candidates without cardiac clearance for transplant.
  • An SPPB score >10 or not considered frail or pre-frail by FP.
  • Non-English speaker without availability of adequate interpreter services (safety concern).

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Cassie Kennedy, M.D.

Open for enrollment

Contact information:

Renee Weatherly

(507)284-4862

weatherly.renee@mayo.edu

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available

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CLS-20421995

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