Metabolic Mapping and Cardiac Resynchronization


About this study

The purpose of this study is to gather information on the safety and effectiveness of cardiac resynchronization therapy (CRT) in patients who have mild heart failure (HF) and left bundle branch block (LBBB).

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Patient is ≥ 18 years of age.
  • LVEF 35%-50%.
  • NYHA class I-II.
  • QRS duration of ≥ 120 ms.
  • Left bundle branch block (LBBB).
  • Patient is able to receive a transvenous pectoral CRT implant.
  • Patient is able to sign informed consent.
  • Two echocardiograms are required to confirm LVEF ≤ 50% (one echo must be within 12 months of enrollment).
  • Patient is on optimal and stable medical therapy (ACE inhibitor or AT1 blocker, beta blocker, etc. over the last 6 months).

Exclusion Criteria:

  • Advanced comorbid conditions with life expectancy <1 year.
  • Patient is < 18 of years of age.
  • Patient has a CRT device.
  • Female patients who is pregnant or not on a reliable form of birth control. Women of childbearing potential are required to have negative pregnancy test within the 7 days prior to device implant.
  • Unwilling or unable to return for required follow-up visits.
  • Patient decides study participation is cost-prohibited.


Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Yongmei Cha, M.D.

Open for enrollment

Contact information:

Hannah Frost CCRP

(507) 293-2762

More information


Publications are currently not available

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