Identification of Non-gal, Non-HLA Antigens in Patients Implanted with Xenogenic Material


About this study

The purpose of this study is to identify non-HLA and non-gal protein antigens in transplanted xenogenic tissues (ie bovine or porcine pericardial heart valves) that can then be used to preemptively identify and overcome graft-specific immune responses.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Patients who will receive either a biological or mechanical heart valve.

Exclusion Criteria: 

  • Currently receiving therapy for cancer requiring treatment with concurrent radiotherapy and/or chemotherapy, cancer in remission for less than 5 years if previously treated with radiotherapy and/or chemotherapy,  previous tissue valve implants, or current pregnancy.

Eligibility last updated 10/13/21. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Leigh Griffiths, Ph.D., MRCVS

Open for enrollment

Contact information:

Rebecca Sweeney

(507) 422-2816

More information


Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available


Mayo Clinic Footer