A Study to Collect Serum Samples from Patients Presenting for Aortic Valve Replacement


About this study

The purpose of this study is to identify non-HLA and non-gal protein antigens in transplanted xenogenic tissues (ie bovine pericardial heart valves) that can then be used to preemptively identify and overcome graft-specific immune responses.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

Inclusion Criteria:

  • Patients who will receive either a biological or mechanical heart valve.

Exclusion Criteria: 

  • History of cancer, autoimmune diseases, or previous valve implants.


Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Leigh Griffiths, Ph.D., MRCVS

Contact us for the latest status

Contact information:

Simon Maltais M.D., Ph.D.


More information


Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available


Mayo Clinic Footer