A Study of DNA Markers for the Detection of Metastatic Melanoma in Blood

Overview

About this study

The purpose of this study is to discover and validate DNA methylation-based markers that identify patients with metastatic melanoma based on the detection of such markers in patient blood with the ultimate goal of using blood-based multi-marker testing as a method of disease surveillance in melanoma patients.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Eligibility will be determined based on clinicopathologic data derived from patient medical records and established by two or more board-certified Mayo Clinic pathologists.

Inclusion Criteria:

CASES and CONTROLS

  • Inclusion criteria are age ≥ 18 years.

CASES

  • Eligible if unequivocally confirmed diagnosis of metastatic melanoma, either by histology or patient history + imaging.

Exclusion Criteria:

CASES and CONTROLS

  • History of an internal malignancy other than melanoma or non-melanoma skin cancer within 5 years prior to blood draw.
  • Ambiguous pathology.
  • Insufficient or poor quality DNA retrievable from blood sample.

CASES

  • Excluded if:
    • all metastatic lesion(s) surgically removed
    • exposed to radiation therapy 7 days prior to blood draw,
    • transplant prior to blood draw iv) surgery or biopsy of any lesion in the 7 days prior to blood draw.

CONTROLS:

  • Excluded if internal malignancy other than melanoma or non-melanoma skin cancer is documented within 3 years after blood draw.

 


     

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Alexander Meves, M.D.

Open for enrollment

Contact information:

Karen Doering M.B.A., CCRP

(507)538-0096

Doering.Karen@mayo.edu

More information

Publications

Publications are currently not available
.

Mayo Clinic Footer