A Study to Compare Enteroendocrine Cells Between Individuals with Obesity and Healthy Volunteers


About this study

The purpose of this study is comparison of enteroendocrine cells between individuals with obesity and health and storage of tissue samples for future research

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Age 18-65 years old.
  • Willing to provide consent.
  • Gender:  men or women.
  • BMI: 18.5-25 healthy subjects, or ≥ 30 with or without “hungry gut” phenotype.

Exclusion Criteria:

  • Individuals who are unable to sign consent (e.g., mentally challenged, those declared legally incompetent).
  • History of abdominal GI surgery other than appendectomy.
  • Bleeding disorder.
  • Positive history of chronic gastrointestinal diseases, or systemic disease that could affect gastrointestinal motility, or use of medications that may alter gastrointestinal motility, appetite or absorption, e.g., orlistat, phentermine.

Any acute or chronic condition or other disease that, in the opinion of the Investigator, would limit the subject’s ability to complete and/or participate in this clinical study.  Participant activities:

  • If recruited for the investigation participants will be asked to refrain from donating blood;
  • Refrain from participating in other research studies;
  •  Avoid taking any additional over the counter or prescription medications or herbal supplements that have not been reviewed and approved by the physician or the study coordinator until the study has been completed.


Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Andres Acosta, M.D., Ph.D.

Closed for enrollment

Contact information:

William Rossini CCRP

(507) 266-7071


More information


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