A Study to Evaluate the Effect of Metformin on Frailty in 12 Subjects (6 Metformin/6 Placebo in a Randomized Fashion)


About this study

The purpose of this study is to test whether chronic metformin administration will improve longevity of the cell, improve its machinery by reducing aging-related biochemical parameters, and improve physical performance as measured by short physical performance battery test.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Age ≥ 60 years
  • CAD
  • Frailty (Short Physical Performance Battery: Score <9)
  • Able to return for follow-up
  • Written informed consent

Exclusion Criteria:

  • Pre-existing or new-onset diabetes
  • Any active malignancy, hematological disorder, post organ transplant, immunocompromised
  • Cancer requiring treatment in the past 3 years (other than non-melanoma skin cancer)
  • Dementia [mini mental state examination (MMSE <20)]
  • Disability (need for assistance in >2 of any six activities on Katz activities of daily living (ADL)46
  • Prior stroke with disability
  • Severe Parkinson's
  • Hepatic insufficiency and/or chronic liver disease (cirrhosis)
  • Chronic kidney disease (GFR < 45 mL/min)
  • Taking metformin for any indication
  • Acute alcohol intoxication
  • Known hypersensitivity to metformin hydrochloride
  • Acute/chronic metabolic acidosis, including diabetic ketoacidosis, with or without coma

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Mandeep Singh, M.D.

Closed for enrollment

More information


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