Effects of Ischemia and Hypoxia on Exercise Tolerance and the Development of Quadriceps Fatigue in Men and Women


About this study

The goal of this study is to determine how neuromuscular fatigue in exercising muscle is influenced by local vs. global oxygen deficit. 

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Non-obese healthy male and female
  • non-smoking participants
  • 18-40 years old with no significant metabolic, cardiovascular, neurologic disease and no contraindications to exercise, as determined by the principle investigator

Exclusion Criteria:

  • Those taking medications that might influence the cardiovascular, respiratory or neuromuscular responses to exercise will also be excluded, on the discretion of the principle investigator (e.g. beta blockers and some other antihypertensives along with anti-asthma drugs)
  • Any subjects with a recent injury to their dominate leg/knee
  • Subjects will also be excluded if they have any metal in their groin area.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Michael Joyner, M.D.

Closed for enrollment

More information


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