A Study to Learn More about Using Sensor Data-Streams and Salivary Cortisol Measurements for the Detection of High and Low-levels of Mental Stress


About this study

The purpose of the current research study is to further the knowledge of how biometric data generated using wearables and other sensing devices relate to different levels of mental stress revealed by endocrine measurements of stress-associated hormone levels and self-reports of perceived stress. 

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

High- and Low-Level Stress Groups-

  1. Adults age 18 to 50
  2. Ability to provide informed consent
  3. Participants are able to wear the Empatica E4 at all times during the study
  4. Participants are able to provide saliva samples for cortisol concentration estimation multiple times throughout the length of the study.

Exclusion Criteria:

  1. Participants with reported history of diagnosed mood or anxiety disorders
  2. Participants taking any medication to treat diagnosed anxiety or mood disorders
  3. Participants who have used steroid-based medications within the past three years
  4. Participants with history of drug/alcohol abuse, and/or current tobacco use.
  5. Women who are pregnant or intend to become pregnant during the duration of the study

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Veronique Roger, M.D.

Closed for enrollment

More information


Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

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