A Study of the Effects of a Hormone Called Glucagon in Glucose Metabolism in People with Pre-diabetes


About this study

The purpose of this study is to understand the effects of a hormone called glucagon in glucose metabolism in people with pre-diabetes.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Nondiabetic subjects in whom genotype at rs7903146 is known
  • Have no history of diabetes and reside within a 100 mile radius of Mayo Clinic, Rochester, MN
  • Subjects will have no known systemic illness, or be taking any medication that could affect glucose metabolism and no history of abdominal surgery (other than appendectomy or tubal ligation).
  • Subjects who do not have diabetes (fasting glucose <100mg/dL and 2hr glucose after a 75g OGTT < 200mg/dl)

Exclusion Criteria:

  • Subjects < 25 years of age or > 70 years of age will not be studied
  • Subjects taking medications that affect glucose metabolism (to be determined by PI)   
  • Individuals with a BMI < 19 or > 40 kg/m2 will be excluded

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Adrian Vella, M.D.

Closed for enrollment

Contact information:

Paula Giesler R.N.

(507) 255-8345


More information


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