A Study of Eosinophil Activities in Healthy Subjects and Subjects with Allergic/immunologic Disorders

Overview

About this study

The purpose of this study is to investigate eosinophil activities and interactions with other cell types in vitro to better understand how they contribute to health and disease.  Specifically, we will isolate eosinophils and other white blood cells from peripheral blood and subject them to various stimuli as well as co-culture conditions to examine activities and interactions. 

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • The normal controls are healthy individuals with no history of eosinophil-associated diseases. 
  • Subjects are healthy individuals except for eosinophil-associated disease conditions as described here. 
  • Patients with asthma are selected based on a diagnosis that includes their histories of recurrent wheezing and chest tightness and an asthma diagnosis from current or previous physicians. 
  • Patients with eosinophilic esophagitis are selected based on diagnosis of EoE from current or previous physicians.

Exclusion Criteria: 

  • Patients who have received systemic glucocorticoids or high-dose (>1,000 µg/day) inhaled glucocorticoids during the past 3 months or who are previous or current smokers will be excluded.
  • Patients who have received oral or swallowed steroids within the past 6 weeks will be excluded.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Benjamin Wright, M.D.

Closed-enrolling by invitation

What is this? (?)
"Close"
Not open to everyone who meets the eligibility criteria, but only those invited to participate by the study team.

Contact information:

Benjamin Wright M.D.

(480) 301-4284

Wright.Benjamin@mayo.edu

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available

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CLS-20357369

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