A Study to Establish Novel Tumor Models Using Scant Tumor Specimens from Solid Tumor Patients


About this study

The objective of this research is to determine the feasibility of establishing organoid tumor models using scant solid tumor tissues obtained by image-guided core needle biopsy procedures during routine clinical care. The routine clinical biopsy may be by image-guidance, endoscopic-guidance (e.g., EGD, colonoscopy, bronchoscopy), direct visualization (e.g., skin biopsy) and surgical exploration. Once established, the tumor organoids’ response to anti-cancer agents will be assessed. If proven feasible, this technique can potentially be integrated into routine clinical care of solid tumor patients and help guide the treatment of the donor patient in the clinic.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Patient must have cytologically or histologically confirmed solid tumor.
  • Should be undergoing biopsy procedure as part of routine clinical care, or whom have consented to collect fresh tissue biopsy.
  • Age 18 years and above.

Exclusion Criteria: 

  • Patients who will be undergoing fine-needle aspiration (FNA) biopsy are excluded.
  • Woman known to be pregnant is excluded.

Eligibility last updated 3/1/22. Questions regarding updates should be directed to the study team contact.


Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Wen Wee Ma, M.B.B.S.

Open for enrollment

Contact information:

Temperance Scheffler Hanson M.H.A., R.N.

(507) 293-0816


Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Tanios Bekaii-Saab, M.D.

Open for enrollment

Contact information:

Laurie Mihalik

(480) 342-3256


More information


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