Recording Breath Acoustics and Lung Mechanics in Patients with COPD, Asthma, and Cystic Fibrosis


About this study

The purpose of this study is to obtain breath acoustic recordings and measures of lung mechanics in patients with COPD, asthma, and cystic fibrosis breathing at rest and during light submaximal exercise. The plan is to examine these respiratory acoustics and mechanics in relation to determinants of disease and/or disease states (classic respiratory pathophysiology) and quality of life measures in these patient populations to determine if any relationship or patterns exist when comparing across respiratory diseases and within a condition based on disease severity.       

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • For the Disease Group Subjects Must Be: 
    • 18 years of age or older 
    • Able to provide consent for participation 
    • Have clinically identified disease:
      • COPD (mild, moderate, severe) 
      • Asthma (mild, moderate, severe) 
      • Cystic fibrosis (mild, moderate, severe) 
  • Healthy subjects must: be 18 years of age or older and able to provide consent for participation.

Exclusion Criteria: 

  • For the Disease Group:
    • Subjects that are unable to consent themselves 
    • Cannot participate in submaximal exercise, or have known cardiovascular disease will be excluded from this study. 
  • For the Healthy Group:
    • Subjects that are unable to consent themselves 
    • Cannot participate in submaximal exercise or, have known cardiovascular or pulmonary disease will be excluded from the study.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Bruce Johnson, Ph.D.

Closed for enrollment

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