Association Between Endothelial Cell Density and Corneal Swelling in Post-Penetrating Keratoplasty Scleral Contact Lens Wear

Overview

About this study

The purpose of this study is to model the relationship between corneal swelling and cell density and determine how this relationship differs by contact lens type.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Please contact the study team to discuss whether or not you are eligible to participate in a study.

Inclusion Criteria:

  1. Post-PK cornea at least 5 years after keratoplasty (rationale: ECD plateaus 5 years post-PK; including corneas that are in the phase of rapid cell loss prior to 5 years will confound the relationships we are studying)
  2. Primary or repeat keratoplasty
  3. May have had cataract extraction and IOL, but may not have history of recent cataract surgery (within 6 months)
  4. Known habitual contact lens parameters if a contact lens wearer

Exclusion Criteria:

  1. Active graft rejection
  2. Graft on the path to failure
  3. Presence of uncontrolled glaucoma (IOP>25 corrected for corneal thickness using OHTS nomogram; because high IOP causes further cell loss)
  4. Active ocular surface disease (infectious conjunctivitis, infectious keratitis, atopic keratoconjunctivitis)
  5. Any optical opacities or ocular disease that decreases best corrected visual acuity (examples: macular degeneration, posterior capsular opacity, corneal opacities on the visual axis)
  6. Indication for PK was pseudophakic or aphakic bullous keratopathy (because this influences graft failure and cell loss)

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Muriel Schornack, O.D.

Open for enrollment

Contact information:

Jane Sultze CCRP

(507) 538-5523

Sultze.Jane@mayo.edu

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available

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CLS-20339564

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