Assessing Glutamine Metabolism in MGUS and Myeloma


About this study

The utilization of glutamine by the bone marrow plasma cells in MGUS and MM will be compared between each other after infusion of 13-carbon labelled glutamine.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • At least 18 years of age.
  • IMWG criteria for the diagnosis of either MGUS or MM.

Exclusion Criteria:

For both MGUS and MM cohorts:

  • < 18 years of age.
  • Unable to provide consent
  • ECOG PS >3
  • Hemoglobin < 8 g/dL
  • Women who are pregnant
  • Prior history of adverse events with conscious sedation.

Eligibility last updated 10/13/21. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Wilson Gonsalves, M.D.

Open for enrollment

Contact information:

Wilson Gonsalves M.D.

(507) 284-5096

More information


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