Clinical and Imaging Factors Associated with Symptoms in Patients with Severe Aortic Stenosis


About this study

The aim of this study is to reveal differences between symptomatic and asymptomatic severe AS patients matched for anatomic (aortic valve area) and hemodynamic (mean gradient) AS severity. The secondary aim is to evaluate functional and prognostic significance of strain value of LV and RV.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Severe AS and normal left ventricular ejection fraction (>50%)

  • Severe AS is defined as mean gradient >40 mm Hg and aortic valve area (AVA) ≤ 1.0 cm2 by 2-dimensional (2-D) and Doppler echocardiography.

 Exclusion Criteria:

  • Age less than 18years

  • Poor echocardiographic images/ difficult to analysis

  • Prior percutaneous aortic balloon valvuloplasty, or prior valve replacement or cardiac surgery

  • Acute coronary syndrome at baseline

  • Infective endocarditis at baseline

  • Patient who is not able to provide reliable descriptions of their symptoms due to dementia

  • Subvalvular left ventricular outflow obstruction

  • End-stage renal disease on chronic dialysis

  • Patient who denies access to his/her record for research



Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Jae Oh, M.D.

Closed for enrollment

Contact information:

Jae Oh M.D.

More information


Publications are currently not available

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