Ultrasound Greater Occipital Nerve Block at C2 Level Compared to Landmark-based Greater Occipital Nerve Block


About this study

This study will compare the analgesic benefit of a traditional landmark-guided GON block with the ultrasound-guided approach over a four week period in patients with occipital neuralgia or cervicogenic headache.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  1. Unilateral or bilateral headache symptoms attributed to occipital neuralgia or cervicogenic headache as defined by the International Headache Society's International Classification of Headache Disorders (3rd edition beta version)
  2. Age 18 years and older (no upper age limit defined)
  3. Imaging of cervical spine within last year (either x-ray, MRI or CT)

Exclusion Criteria:

  1. History of cervical spine surgery, trauma, or surgical procedure involving head or neck during the last year
  2. Use of new preventative medications 1 month prior or during study enrollment
  3. Evidence of impaired sensation in the GON dermatome region (posterior scalp to the vertex of the cranium) from neurological, dermatological, or other disease process
  4. Evidence of cranial defect or other anatomical abnormality near the target injection site
  5. History of bleeding diathesis, coagulopathy, or current use of anticoagulant medications
  6. Pregnancy
  7. History of adverse reaction or allergy to local anesthetic agents or corticosteroids
  8. Occipital nerve block within the past three months.
  9. Unavailability for appropriate follow-up throughout the whole duration of study

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Matthew Pingree, M.D.

Closed for enrollment

More information


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Study Results Summary

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Supplemental Study Information

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