The Use of Human Mesenchymal Stem Cell Technology for Treatment of Mandibular Osteoradionecrosis

Overview

About this study

We are currently working on a research project to investigate the use of stem cells to regenerate bone in the jaw that is unhealthy as a result of osteoradionecrosis (ORN). Stem cells have the capability to develop into bone, cartilage, fat, skin or blood vessels, and are thought to be involved in the healing process. Using your discarded jawbone (if this is being removed) and/or fat, we can generate stem cells and see if they can heal the bone in the laboratory setting. If this proves successful, we may be able to use this technology in patients to avoid extensive surgery.

In order to test this idea, the segment of your jawbone (if this is being removed) and/or fat which is routinely discarded as waste will be sent for testing. Our goal is generate stem cells for replacement of bone from patients suffering from this disease.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

Inclusion Criteria:

  1. Manidbular bone, as well as fat (from the neck and donor site) , will be harvested in any patient undergoing manidbular reconstruction for osteoradionecrosis

    OR

  2. Fat (from the neck and donor site) will be harvested from any patient undergoing tumor ablation and subsequent reconstruction with a prior history of head and neck irradiation

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Jeffrey Janus, M.D.

Closed for enrollment

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available

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CLS-20320104

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