A Study to Assess the Effectiveness, Safety, Tolerability, and Drug/Body Interactions of ABBV-8E12 in Progressive Supranuclear Palsy


About this study

The purpose of this study is to assess the effectiveness, safety, tolerability, and drug/body interactions of ABBV-8E12 for the treatment of patients who have progressive supranuclear palsy.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

  • Male or female
  • Age 40 years or greater at the time of signed consent
  • Meets criteria for possible or probable progressive supranuclear palsy (Steele-Richardson-Olszewski Syndrome)
  • Presence of PSP symptoms for less than 5 years
  • Able to walk 5 steps with minimal assistance, with stabilization of one arm or use of cane or walker
  • Has an identified, reliable, study partner (e.g., caregiver, family member, social worker, or friend)

Exclusion Criteria

  • Weighs less than 44 kg (97 lbs) at screening
  • MMSE score less than 15 at screening
  • Any contraindication or inability to tolerate brain magnetic resonance imaging (MRI)
  • Resides at a skilled nursing or dementia care facility, or admission to such a facility is planned during the study period
  • Evidence of any clinically significant neurological disorder other than PSP
  • A history of or currently has schizophrenia, schizoaffective disorder or bipolar disorder according to DSM-V or ICD-10 criteria
  • Has had a significant illness or infection requiring medical intervention in the past 30 days

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Jacksonville, Fla.

Mayo Clinic principal investigator

Zbigniew Wszolek, M.D.

Closed for enrollment

Rochester, Minn.

Mayo Clinic principal investigator

James Bower, M.D.

Closed for enrollment

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Erika Driver-Dunckley, M.D.

Closed for enrollment

More information


Publications are currently not available

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