Oncogene-­-Induced Secretion of Extracellular Matrix Proteins in Squamous Cell Carcinoma of the Skin


About this study

The purpose of this study is:

Define a set of differentially regulated secreted proteins in human cancer cells across all stages of cancer progression

  • Identify a set of 32 genes (including housekeeping genes) that encode for secreted proteins that correlate with disease progression using a bioinformatics approach
  • Design probe sets for RT-PCR and run a pilot study both on FFPE and fresh tissue
  • If the pilot is successful, expand the data set to an n of 100. Include SCCs of various differentiation and anatomical location. Include SCCs from transplant patients.

Correlate the results of the RT-PCR panel to the biological behavior of the tumor

  • The following variables will be examined:
    • Differentiation
    • Ability to metastasize
    • Response to therapy

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  1. All tissue collected will be from sun-exposed sites
  2. All tissue will be from adult patients (18 years and older)

Exclusion Criteria:

  1. Children (below 18 years of age) are excluded from the study

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Alexander Meves, M.D.

Open for enrollment

Contact information:

Jennifer Winters


More information


Publications are currently not available

Study Results Summary

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Supplemental Study Information

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