The Effects of Aortic Valve Replacement on Sleep Disordered Breathing, Heart Rate Variability and Ventricular Ectopy Burden in Patients with Severe Aortic Stenosis

Overview

About this study

Our overall goal is to determine whether the AVR improves SDB where present and sleep profiles (including sleepiness symptoms, quality of life and hypoxia).

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:              

  • Adults: >18 years

  • Patients with severe AS (valve area ≤1 cm2, mean gradient ≥40 mmHg, or peak velocity ≥4.0 m/s), or clinically severe aortic stenosis in the context of low-gradient and/or low ejection fraction.

     

    Exclusion Criteria:            

  • Patients who have other significant valvular disease (warranting surgery or intervention)

  • Patients who have known SDB and have received treatment (current or active). Patients with a known diagnosis of SDB but have never received treatment are eligible.

  • Patients who are unable to consent

  • Children/adolescents under age 18 years

  • Pregnancy (women known to be pregnant)

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Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Vuyisile Nkomo, M.D., M.P.H.

Closed for enrollment

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available

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CLS-20317442

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