A Study of Genes Responsible for Joint Contractures in People Who Have Had Total Joint Surgery


About this study

The purpose of this study is to learn why there are differences between those who develop stiff joints and those who do not by examining the genes responsible for joint contractures in people who have had total joint surgery.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Group IA

  • Patients with open elbow procedures or trauma which have resulted in arthrofibrosis of the elbow joint  

Group IB

  • Patients with normal motion  

Group IIA 

  • Patients with established shoulder contractures limiting ADL’s 

Group IIB

  • Normal patients 

Group IIIA 

  • Patients with knee arthrofibrosis after TKA  

Group IIIB

  • Patients without contracture after TKA

Exclusion Criteria:

  • Age less than 18 years
  • History of infection in operative extremity
  • History of malignancy in operative extremity
  • Presence of a condition

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Joaquin Sanchez-Sotelo, M.D., Ph.D.

Closed for enrollment

Contact information:

Jessica Stutzman

(507) 266-1227


More information


Publications are currently not available

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