A Study of Genes Responsible for Joint Contractures in People Who Have Had Total Joint Surgery


  • Study type

  • Study IDs

  • Describes the nature of a clinical study. Types include:

    • Observational study — observes people and measures outcomes without affecting results.
    • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
    • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
  • Site IRB
    • Rochester, Minnesota: 10-006234
    Sponsor Protocol Number: 10-006234

About this study

The purpose of this study is to learn why there are differences between those who develop stiff joints and those who do not by examining the genes responsible for joint contractures in people who have had total joint surgery.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

See eligibility criteria

Inclusion Criteria:

Group IA

  • Patients with open elbow procedures or trauma which have resulted in arthrofibrosis of the elbow joint  

Group IB

  • Patients with normal motion  

Group IIA 

  • Patients with established shoulder contractures limiting ADL’s 

Group IIB

  • Normal patients 

Group IIIA 

  • Patients with knee arthrofibrosis after TKA  

Group IIIB

  • Patients without contracture after TKA

Exclusion Criteria:

  • Age less than 18 years
  • History of infection in operative extremity
  • History of malignancy in operative extremity
  • Presence of a condition

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Joaquin Sanchez-Sotelo, M.D., Ph.D.

Open for enrollment

Contact information:

Charlene Blanchard




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